Clearing debris.

Meng D, Jewell JL.

Nat Chem Biol. 2019 Aug;15(8):760-761. doi: 10.1038/s41589-019-0320-8.

PMID: 31285594


GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL.

Elife. 2019 May 21;8. pii: e43038. doi: 10.7554/eLife.43038.

PMID: 31112131


mTOR signaling in stem and progenitor cells.

Meng D, Frank AR, Jewell JL.

Development. 2018 Jan 8;145(1). pii: dev152595. doi: 10.1242/dev.152595. Review.

PMID: 29311260


Amino acid and small GTPase regulation of mTORC1.

Nguyen TP, Frank AR, Jewell JL.

Cell Logist. 2017 Sep 29;7(4):e1378794. doi: 10.1080/21592799.2017.1378794. eCollection 2017. Review.

PMID: 29296509


NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.

Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL.

Genes Dev. 2015 Nov 15;29(22):2362-76. doi: 10.1101/gad.265116.115.

PMID: 26588989


Micro(RNA) managing by mTORC1.

Jewell JL, Flores F, Guan KL.

Mol Cell. 2015 Feb 19;57(4):575-576. doi: 10.1016/j.molcel.2015.02.006.

PMID: 25699705


Metabolism. Differential regulation of mTORC1 by leucine and glutamine.

Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL.

Science. 2015 Jan 9;347(6218):194-8. doi: 10.1126/science.1259472. Epub 2015 Jan 7.


Rag GTPases are cardioprotective by regulating lysosomal function.

Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL.

Nat Commun. 2014 Jul 1;5:4241. doi: 10.1038/ncomms5241.

PMID: 24980141


Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation.

Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL.

Genes Dev. 2013 Jun 1;27(11):1223-32. doi: 10.1101/gad.219402.113.

PMID: 23752589


Nutrient signaling to mTOR and cell growth.

Jewell JL, Guan KL.

Trends Biochem Sci. 2013 May;38(5):233-42. doi: 10.1016/j.tibs.2013.01.004. Epub 2013 Mar 1. Review.

PMID: 23465396


Amino acid signalling upstream of mTOR.

Jewell JL, Russell RC, Guan KL.

Nat Rev Mol Cell Biol. 2013 Mar;14(3):133-9. doi: 10.1038/nrm3522. Epub 2013 Jan 30. Review.

PMID: 23361334


Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.

Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL.

Cell. 2012 Aug 17;150(4):780-91. doi: 10.1016/j.cell.2012.06.037. Epub 2012 Aug 2.

PMID: 22863277


Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis.

Jewell JL, Oh E, Ramalingam L, Kalwat MA, Tagliabracci VS, Tackett L, Elmendorf JS, Thurmond DC.

J Cell Biol. 2011 Apr 4;193(1):185-99. doi: 10.1083/jcb.201007176. Epub 2011 Mar 28.

PMID: 21444687


Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4.

Jewell JL, Oh E, Thurmond DC.

Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R517-31. doi: 10.1152/ajpregu.00597.2009. Epub 2010 Jan 6. Review.

PMID: 20053958


The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2beta.

Jewell JL, Oh E, Bennett SM, Meroueh SO, Thurmond DC.

J Biol Chem. 2008 Aug 1;283(31):21734-46. doi: 10.1074/jbc.M710445200. Epub 2008 Jun 9.

PMID: 18541526


Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4.

Jewell JL, Luo W, Oh E, Wang Z, Thurmond DC.

J Biol Chem. 2008 Apr 18;283(16):10716-26. doi: 10.1074/jbc.M709876200. Epub 2008 Feb 19.

PMID: 18285343