https://www.jewelllab.org/contact-1 daily 0.75 2025-12-17 https://www.jewelllab.org/meet-the-pi daily 0.75 2025-12-17 https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/4e209402-5ea4-4759-b646-105ffa51f5b7/Screenshot+2025-12-15+at+1.48.09%E2%80%AFPM.png Meet the PI - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.jewelllab.org/lab-members-1 daily 0.75 2025-12-17 https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1622665463240-FQSKDES6PUOBLNAMU0CT/IMG_4245.jpg https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1622665721844-JQ8TI1VR6JJMFDIR2C4C/IMG-20191115-WA0006.jpg https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/c8cce657-2e3d-4d5e-9380-18c37181d782/Screenshot+2024-04-26+at+11.30.12%E2%80%AFAM.png https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/bd8261a6-d439-4bbc-8ffd-54f93594b5b0/IMG_6540.jpeg https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1622666165230-BDAD5ANL5KMTT7BEJ6P0/Screen+Shot+2021-06-02+at+3.30.30+PM.png https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/c95725d3-7829-4b09-90e0-4168eaa7c104/20211228_131606.jpg https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/dd6e7829-e925-4f11-92cb-113d5fd07d26/Screenshot+2024-04-26+at+11.41.23%E2%80%AFAM.png https://www.jewelllab.org/research daily 0.75 2025-12-17 https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/c24d3859-c279-46cf-80c8-ea828840d021/Screenshot+2025-12-16+at+12.25.01%E2%80%AFPM.png Research - Make it stand out Nutrients are sensed by cells to regulate growth, metabolism, and autophagy, and disruption of these processes contributes to human disease. The mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase and the catalytic component of mTOR complex 1 (mTORC1), a central signaling hub that integrates nutrient availability to coordinate these cellular responses. Often described as a master regulator of cell growth, mTORC1 promotes anabolic processes such as protein synthesis while suppressing catabolic pathways, including autophagy. The Jewell laboratory is interested in understanding how mTORC1 activity is controlled by upstream signals. Our research focuses on two major areas: (1) activation of mTORC1 in response to amino acids, particularly glutamine (Gln) and asparagine (Asn) (Figure A), and (2) regulation of mTORC1 by G protein–coupled receptor (GPCR) signaling (Figure B). In particular, we investigate GPCRs coupled to Gαs proteins and their role in inhibiting mTORC1 signaling. mTORC1 activity is elevated in a wide range of human diseases, including cancer, yet current therapies targeting this pathway have shown limited clinical benefit. By defining the molecular mechanisms that regulate mTORC1, our work aims to identify new strategies for more effective therapeutic intervention. https://www.jewelllab.org/new-page daily 1.0 2026-01-05 https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/220c53f2-650b-41a6-913b-428fc84b4a7a/Main+Figure3+shutterstock_Cell29257576.png Home https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/fda377f6-56f1-46f3-8076-2f1d132e85b9/Main+Figure3+shutterstock_Cell29257576.png https://www.jewelllab.org/publications daily 0.75 2025-12-17 https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/547a27c9-7dca-4d04-8e0a-89364afced54/Screenshot+2023-07-11+at+1.12.51+PM.png Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1622584256218-8RJXMYWMJ04TVIYEQZOR/JBC-cover.png Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/547a27c9-7dca-4d04-8e0a-89364afced54/Screenshot+2023-07-11+at+1.12.51+PM.png Publications - 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Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1566246519995-2RVW32R6VLVI7MC04F70/IMG_0018.JPG News https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/a8a41c57-8db6-4697-8de3-dda14d4bb346/Screenshot+2025-12-16+at+1.04.40%E2%80%AFPM.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/c58bbc91-4c66-4ec2-ba68-13fdaee40cf8/Screenshot+2023-07-11+at+1.36.57+PM.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1552085025947-NLK07Q1YJ2NLLBU49865/image.png News https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1552085034548-TXJSIPBH5UWT96TSPIAY/image.png News https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1622667661256-ZT4AE834ALHPRTHLYCJF/Screen+Shot+2021-06-02+at+4.00.43+PM.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1622667762062-4GGE8B6R8CR2ANV3Q7Z5/Screen+Shot+2021-06-02+at+4.02.32+PM.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1566244329751-KF6DQ0IJPVWJ8FRL9EVO/IMG_0015.JPG News https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1566244699204-BLNW1UZRQQP1Q0YTX2ZM/IMG_0017.jpg News https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1f9a94e4-85fb-49a6-8b81-6a44cc05673e/F8DDFAE2-A2F3-414F-A3F9-44F5FD2693C9.JPG News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/f5fbc5b2-b71f-4489-9dca-a0bf645b6145/Screenshot+2025-12-16+at+1.14.09%E2%80%AFPM.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/0887b255-72ff-406b-8da5-5833f6c6897f/Screenshot+2023-07-11+at+1.51.49+PM.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/c096d528-76b9-483f-8596-84fefb73d703/Screenshot+2023-07-11+at+1.55.12+PM.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.jewelllab.org/new-page-2 daily 0.75 2025-12-17 https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/0096f913-36e2-4503-b3d4-66674dff9625/IMG_8450.jpg Pet Support Team Kitty: Head of Photography & Press Release https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/aa0b8dfd-3295-4b54-86a6-7841288a9665/IMG_9066.jpeg Pet Support Team Zoe: Coordinator of Stress Release https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/9f596ec1-6f37-412b-b9ea-8c8632404451/IMG_3313.jpeg Pet Support Team Nacho: Head of Communications & Social Chair https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1da0502d-1339-44ea-95fd-ef74ea63c239/IMG_9069.jpeg Pet Support Team Cosmo: Senior Lunch Supervisor https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/d6745c16-1f79-4e15-a4ce-eb363e752d8e/16BC2A93-D831-4F90-8016-B03A7809C659.jpeg Pet Support Team - Make it stand out Kobe & Venus: Senior Tech Team https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/fc8a379b-3cc8-4abd-b3ec-6e91b6a6d7de/IMG_9074.jpeg Pet Support Team - Make it stand out Ollie: Head of Lab Outings and Retreats https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/5ffb5dd9-37fe-4500-a883-f26ab06686c9/IMG_1140.jpeg Pet Support Team Mushi: Head of Lab Security & Safety https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/1da0502d-1339-44ea-95fd-ef74ea63c239/IMG_9069.jpeg Pet Support Team Cosmo Senior Lunch Supervisor https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/aa0b8dfd-3295-4b54-86a6-7841288a9665/IMG_9066.jpeg Pet Support Team Zoe Coordinator of Stress Release https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/0096f913-36e2-4503-b3d4-66674dff9625/IMG_8450.jpg Pet Support Team Kitty Head of Photography & Press Release https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/fc8a379b-3cc8-4abd-b3ec-6e91b6a6d7de/IMG_9074.jpeg Pet Support Team - Make it stand out Ollie Head of Lab Outings and Retreats https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/9f596ec1-6f37-412b-b9ea-8c8632404451/IMG_3313.jpeg Pet Support Team Nacho Head of Communications & Social Chair https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/5ffb5dd9-37fe-4500-a883-f26ab06686c9/IMG_1140.jpeg Pet Support Team Mushi Head of Lab Security & Safety https://images.squarespace-cdn.com/content/v1/5c7dacee4d87116c20d7e1ec/d6745c16-1f79-4e15-a4ce-eb363e752d8e/16BC2A93-D831-4F90-8016-B03A7809C659.jpeg Pet Support Team - Make it stand out Kobe & Venus Senior Tech Team